Advances in next-generation sequencing platforms have reshaped the landscape of genomic and epigenomic research as well as human genetics studies. Annotating the non-coding, regulatory genome with genomic and epigenomic data has provided new venues to interpret the functional consequences of genetic variants associated with human complex traits. Large consortiums such as ENCODE, Roadmap Epigenomics, and 4D Nucleome projects have generated tens of thousands of sequencing-based genome-wide datasets, creating a reference and resource for the scientific community. There is a great need for investigators to effectively engage with this resource in the context of analyzing investigators’ own data.
This interactive workshop will introduce genomic resources produced by consortiums including ENCODE, Roadmap Epigenomics, and 4DN, and the WashU Epigenome Browser and associated tools (http://epigenomegateway.wustl.edu/). The Epigenome Browser hosts hundreds of thousands of genomic datasets produced by large consortiums and investigators, and supports navigation of the data and its interactive visualization, integration, comparison, and analysis. Attendees will gain hands-on experience with exploring the most current epigenomic resources, and with advanced visual-bioinformatics tools including gene set view, genome juxtaposition, and chromatin-interaction display, inventions unique to the WashU Epigenome Browser. Through specific examples, the workshop will demonstrate the power of “big bio-data”.
Tuesday July 9, 1:30 PM – 3:30 PM
Bell Harbor International Conference Center, Seattle, WA
chr1:1045099-1045732 chr1:1253756-1254042 chr1:1545345-1545429 chr1:1617801-1617888 chr1:1790105-1790455 chr1:1814987-1815095 chr1:1828629-1828773 chr1:1927723-1927931 chr1:2107510-2107829 chr1:3398974-3399081 chr1:3492059-3492417 chr1:3577197-3577986 chr1:3691608-3691772 chr1:3709956-3710478 chr1:3724332-3724667 chr1:3786598-3786703 chr1:4068006-4068170 chr1:5916634-5917048 chr1:5953222-5954230 chr1:5977802-5978150
Workshop at 2015 Keystone: Epigenomic Annotation of Transposable Elements Using The Washington University Epigenome Browser.
Workshop at 2014 ASHG: Epigenomic Annotation of Genetic Variants Using The Washington University Epigenome Browser.