There has been increasing awareness of the interplay between mutations and epimutations in driving the initiation and progression of cancer. Specific genetic mutations of epigenetic regulators may cause widespread epigenetic alterations, and epimutations similarly predispose to genetic alterations either locally or across the genome. The field has seen a dramatic shift in the past decade from a pure genetic to a mixed genetic/epigenetic explanation of cancer. From the discovery of the alterations, along with significant structural biology and chemistry, new agents with therapeutic potential have arisen. This GRC series focuses on the discovery and functional characterization of novel recurrent genetic and epigenetic alterations, the molecular mechanisms underlying epigenetic mutations and epigenetic changes in cancer, as well as the development and applications of epigenetic therapies in cancer. Recent discoveries on tumor heterogeneity and tumor immunity as well as their interactions with cancer epigenetics also bring new excitement to the field. The development of high throughput "omics" techniques, such as mutational and epigenetic profiling, chemical and genetic screens, proteomics, has greatly accelerated research in this area. Need for computational algorithms and analyses integrating such "omics" data to model epigenetic regulation in cancer also becomes critical. Developments and discoveries on cancer genetics and epigenetics will have far-reaching implications to our capacity to understand tumor initiation and progression, to decipher the pathways and molecules involved, as well as to devise new strategies for prevention and treatment. We hope to attract leaders from academia and industry for stimulating discussions on cancer genetics and epigenetics, from mutation profiles, to mechanistic and functional characterization, to cancer therapies.
This interactive workshop will introduce The WashU Human Epigenome Browser and associated tools (http://epigenomegateway.wustl.edu/). The Epigenome Browser hosts ENCODE data and Human Epigenome Atlas data produced by the Roadmap Epigenomics project, and support navigation of the data and its interactive visualization, integration, comparison, and analysis. Attendees will gain hands-on experience with exploring the most current epigenomic resources, and with advanced visual-bioinformatics tools including gene set view, genome juxtaposition, and chromatin-interaction display, inventions unique to the WashU Epigenome Browser. Through specific examples the workshop will demonstrate the power of the Epigenome Browser.
1:30-3:30 PM on Apr 25
Renaissance Tuscany Il Ciocco
Lucca (Barga), Italy
Workshop at 2015 Keystone: Epigenomic Annotation of Transposable Elements Using The Washington University Epigenome Browser.
Workshop at 2014 ASHG: Epigenomic Annotation of Genetic Variants Using The Washington University Epigenome Browser.